Amylase test

Amylase Test

Amylase

Amylase is an enzyme that changes complex sugars (starches) into simple sugars during digestion. Levels of amylase in the blood can be used to help diagnose and monitor diseases, such as diseases of the pancreas and salivary glands, or to determine whether the intestines have been damaged.

There are two kinds of amylase enzymes:

  • Salivary amylase (ptyalin), which is produced by the salivary glands. This enzyme begins starch digestion in the mouth and continues to work in the stomach.
  • Pancreatic amylase, which is secreted by the pancreas into the small intestine. This enzyme continues the starch digestion process.

Why is an amylase test done?

A test for amylase is done to:

  • Find pancreatitis and other pancreatic diseases.
  • See if the treatment for pancreatitis and other pancreatic diseases is working.
  • Check swelling and inflammation of the salivary glands.

How is an amylase test done?

Blood test

A health professional uses a needle to take a blood sample, usually from the arm.

Urine test

Amylase can be measured in a 24-hour urine sample. You must collect all the urine you produce in a 24-hour period.

  • You start collecting your urine when you wake up. When you first get up, empty your bladder, but don't save this urine. Write down the time that you urinated to mark the start of your 24-hour collection period.
  • For the next 24 hours, collect all your urine. Your doctor or lab will usually provide you with a large container that holds about 1 gallon. The container may have a small amount of preservative in it. Urinate into a small, clean container, and then pour the urine into the large container. Do not touch the inside of the containers with your fingers.
  • Keep the large container in the refrigerator for the 24 hours.
  • Empty your bladder for the final time at or just before the end of the 24-hour period. Add this urine to the large container, and record the time.
  • Do not get toilet paper, pubic hair, stool (feces), menstrual blood, or other foreign matter in the urine sample.

How do you prepare for an amylase test?

  • In general, you don't need to prepare before having this test. Your doctor may give you some specific instructions.
  • For 24-hour urine collection, your doctor or lab will usually give you a large container that holds about 1 gallon.

What do the results of an amylase test mean?

Normal

Each lab has a different range for what's normal. Your lab report should show the range that your lab uses for each test. The normal range is just a guide. Your doctor will also look at your results based on your age, health, and other factors. A value that isn't in the normal range may still be normal for you.

High values

Values may be high because of:

  • Inflammation of the pancreas (pancreatitis), a pancreatic cyst, or cancer of the pancreas.
  • Inflammation of the salivary glands, such as mumps.
  • Blockage of, or severe damage to, the intestines (bowel obstruction or strangulation).
  • A stomach ulcer that caused a hole in the stomach wall.
  • Gallstones that are causing pancreatitis.
  • Diabetic ketoacidosis.
  • A ruptured ectopic pregnancy.
  • Kidney failure.
  • Appendicitis or peritonitis.
  • Macroamylasemia, an uncommon and harmless condition in which amylase is bound to a protein in the blood.

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